> ## Content Index > Fetch the complete content index at: https://www.sanarelab.science/llms.txt > Use this file to discover other available public pages before exploring further. # Nine New Curcumin-Derived Compounds Built — One Beat Cisplatin Against Colon Cancer Cells in the Dish - URL: https://www.sanarelab.science/ef24-n-benzoyl-analogs-colorectal-cancer-cells-2026/ - Published: 2026-10-06T08:17:54.000Z - Updated: 2026-10-12T12:31:11.000Z - Description: Nine new N-benzoyl analogs of EF24, a synthetic curcumin derivative, were made; compound 10 was more cytotoxic than EF24 and cisplatin against HT-29 colon cancer cells in vitro. - Author: Sanare Lab - Tags: #short-read, News, Research, Repurposed Drugs Key Takeaway EF24 is a lab-made version of curcumin (the yellow compound in turmeric). Chemists built nine new variants; in dish tests on colon cancer cells, one beat both EF24 and cisplatin, a common chemo drug. Very early work — no animals or patients yet. The team made nine N-benzoyl analogs of EF24 (variants with a swapped chemical group) and tested them on HT-29 colon cancer cells with an MTT assay — a color-based count of living cells — at 24 and 48 hours. Related reading: [ivermectin and RMETASE in colon cancer cell studies](https://www.sanarelab.science/ivermectin-rmetase-colon-cancer-2026/). Four (compounds 4, 5, 7, 10) were significantly cytotoxic — they killed cancer cells. Compound 10 beat both EF24 and cisplatin. In molecular docking (computer simulations of how a molecule fits its target), it bound best to glyoxalase I, an enzyme cancer cells use to neutralize toxic waste. The abstract gives no exact potency numbers, and the authors say animal and pharmacokinetic studies (how the body handles a drug) are still needed. See [what curcumin research shows overall](https://www.sanarelab.science/curcumin-and-cancer-what-human-and-preclinical-research-actually-shows/) and [curcumin in a 577-patient colorectal trial](https://www.sanarelab.science/curcumin-curbs-colorectal-polyp-regrowth-577-patient-rct-2026/); dosing questions: our [dosing calculator](https://www.sanarelab.science/protocol-dosing-workspace/). ## In plain words **What happened:** Chemists built nine new variants of EF24, a man-made improved curcumin, and tested them on colon cancer cells in lab dishes. **Why it matters:** Natural curcumin is weak and poorly absorbed, so chemists keep redesigning it. One variant killed colon cancer cells better than EF24 and a chemo drug in dishes, and fit best into a self-defense enzyme in computer simulations. **How strong is the evidence:** Very early: synthesis plus cells in dishes — no animals, no people, no exact potency numbers in the summary. A real drug candidate is years away, if ever. **What it means for you:** Nothing changes today — these are not available or proven treatments. Do not self-experiment; curcumin supplements are not these lab compounds. ## Shop Sanare Lab Lab-tested products referenced in the research above — order direct from Sanare Lab. ![Curcumin 360 mg](https://storage.ghost.io/c/71/33/71331401-900c-4129-b24f-ec3d045b8350/content/images/2026/10/02bf6f7944ec441d91c74baa2c2054bf.png) Daily adjunct ### Curcumin 360 mg 95% curcuminoids with black pepper extract. 120 capsules **$19.99** [Buy at Sanare Lab](https://sanarelab.com/products/curcumin-turmeric-360-mg-120-capsules?ref=sanarelab.science) Prices checked September 2026 and may change; the store page shows the current price. **Disclaimer:** Links are informational and for convenience. This site does not provide medical advice. Always verify product [quality](https://www.sanarelab.science/where-to-buy-fenbendazole/), labeling, and consult a licensed professional for health decisions. ## References 1. Khademi Moughari F, Ebrahimi Kiasari R, Ghavami G, et al. Synthesis, in vitro and in silico studies of novel N-benzoyl EF24 analogs as potential anticancer agents (in vitro = cells in lab dishes; in silico = computer simulations). *Future Medicinal Chemistry*. 2026 Oct 4\. [doi:10.1080/17568919.2026.2726189](https://doi.org/10.1080/17568919.2026.2726189?ref=sanarelab.science). [PMID: 42830631](https://pubmed.ncbi.nlm.nih.gov/42830631/?ref=sanarelab.science). ## Medical Disclaimer This article is for informational purposes only and is not medical advice. The study was done in cells and computer simulations, not in animals or humans. Never start, stop or change any medication or supplement without consulting your doctor.